- This funding opportunity is intended to promote innovative research across multiple disciplines for better understanding of the biology, etiology, detection, prevention, and treatment of pancreatic cancer.
- Examples of appropriate research areas include, but are not limited to: Identification of genetic aberrations (e.g., mutations, epigenetic changes, etc.) or combinations of aberrations alterations that initiate or promote pancreatic cancer; Development of experimental models for human pancreatic cancer to facilitate the understanding of molecular carcinogenesis, to help to identify promising molecular targets, and to test new preventive/therapeutic strategies; Exploration of molecular pathways using human cell lines and/or tissues to identify possible novel targets for prevention or therapeutic development; Identification of markers for early detection of cancer; Conduct of preclinical studies to identify candidate chemopreventive drug(s) and dietary factors for prevention and to characterize the molecular mechanism(s) of the agent's activity; Conduct of small exploratory clinical trials with a potential chemopreventive agent (e.g., a farnesyltransferase inhibitor or a sta!
tin) assessing response via endoscopic ultrasound or another similar technology; Development of early-stage clinical trials in pancreatic cancer prevention and therapy; Assessment of any associations of tumor pathophysiology on tumor development, progression, and preventive/therapeutic response; Conduct of exploratory studies to identify and evaluate biomarkers (with associated assay development) to determine prognosis and predict response to therapy in pancreatic cancer; Evaluation of combination therapies for pancreatic cancer; Identification of new' environmental exposures (e.g., adverse energy balance) that may contribute to pancreatic cancer development, including adverse energy balance; Assessment of the impact of pancreatic cancer on health-related quality of life of patients and their caregivers; and Conduct of pilot surveillance studies and generation of survivorship registries.
- Because the nature and scope of the proposed research will vary from application to application, it is anticipated that the size and duration of each award will also vary. The total amount awarded and the number of awards will depend upon the mechanism, numbers, quality, duration, and costs of the applications received.
- This PA involves use of the R03 and R21 mechanisms. The R03 mechanism supports small research projects that can be carried out in a short period of time with limited resources. The R21 mechanism is intended to encourage new exploratory and developmental research projects. As an applicant, you will be solely responsible for planning, directing, and executing the proposed project.
- You may submit (an) application(s) if your organization has any of the following characteristics: For-profit organizations; Non-profit organizations; Public or private institutions, such as universities, colleges, hospitals, and laboratories; Units of State or local governments; Eligible agencies of the Federal government; Domestic Institutions; Foreign Institutions; and/or Faith-based or community-based organizations.
- Applicants may submit more than one application, provided that they are scientifically distinct.
- See Section IV for application and submission information.
- Telecommunications for the hearing impaired is available at: TTY 301-451-0088
Who can apply:
City Or Township Governments
Federally Recognized Indian Tribal Governments
Independent School Districts
Native American Organization
Non-Government - General
Nonprofits Having A 501(C)(3) Status With The IRS, Other Than Institutions Of Higher Education
Nonprofits That Do Not Have A 501(C)(3) Status With The IRS, Other Than Institutions Of Higher Education
Other Private Institution/Organization
Private Institutions Of Higher Education
Private Nonprofit Institution/Organization (Includes Institutions Of Higher Education, Hospitals)
Public And State Controlled Institutions Of Higher Education
Public Housing Authorities/Indian Housing Authorities
Quasi-Public Nonprofit Institution/Organization
Small Business (Less Than 500 Employees
Special District Governments
State (Includes District Of Columbia; Includes Institutions Of Higher Education And Hospitals)
U.S. Territories And Possessions (Includes Institutions Of Higher Education, Hospitals)
Eligible functional categories:
Cancer Cause and Prevention Research
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